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What is Injectable I-PRF?

 What is Injectable I-PRF?
What is Injectable I-PRF?

Injectable Platelet-Rich Fibrin (I-PRF) is an innovative treatment method rapidly gaining popularity in biological medicine. Like Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), I-PRF is a biomaterial derived from the patient's own blood. However, I-PRF shows some significant differences compared to PRP and PRF, making it unique in its application across various medical treatments.

How is I-PRF Obtained?

I-PRF is obtained by centrifuging the patient's blood at a low speed. This process allows the blood components to separate. Low-speed centrifugation allows more leukocytes and platelets to integrate into the fibrin matrix. This results in a higher cellular concentration and healing potential. The I-PRF is then injected into the target area with a fine needle.

Advantages of I-PRF

Naturalness and Biocompatibility

I-PRF is entirely derived from the patient's own blood, minimizing the risk of allergic reactions or infections. This makes the treatment process safer.

Long-lasting Effect

I-PRF contains slow-release growth factors. This ensures that the healing process continues for an extended period, helping to achieve more permanent results.

Cellular Density

Compared to PRP, I-PRF offers a higher cellular density, meaning more growth factors and healing components.

What Treatments is I-PRF Used For?

I-PRF has a wide range of applications and can be used in various medical and aesthetic treatments.


I-PRF is commonly used in dentistry for procedures such as implant placement, bone grafting, and gum regeneration. Growth factors accelerate bone and soft tissue healing, reducing treatment time.

Orthopedics and Sports Medicine

In orthopedic treatments, I-PRF is used to heal joint, muscle, and tendon injuries. It is especially beneficial for athletes and individuals with active lifestyles.

Dermatology and Aesthetic Applications

I-PRF is used in aesthetic procedures such as skin rejuvenation, scar treatment, and hair loss treatment. Injected under the skin, I-PRF stimulates collagen production, making the skin look younger and healthier.

I-PRF Application Process


First, a certain amount of blood is drawn from the patient. This blood is placed in a special tube and centrifuged at a low speed. At the end of the centrifugation process, I-PRF is obtained.


The obtained I-PRF is injected into the target area under sterile conditions. This process is minimally invasive and is usually done under local anesthesia.

Recovery Process

Patients can generally return to their daily activities immediately after the I-PRF injection. However, there may be slight swelling or bruising in the injection area, which usually subsides within a few days.

Differences Between I-PRF and PRP

Although both I-PRF and PRP are biomaterials derived from the patient's own blood, there are some key differences:


PRP has a higher platelet concentration, but I-PRF is richer in leukocytes and growth factors.

Duration of Effect

PRP shows a quick effect, while I-PRF provides a longer-lasting healing process due to its slow-release growth factors.

Application Areas

Both treatments have a wide range of applications, but I-PRF is preferred for situations requiring a denser cellular structure and long-lasting effect.

The Future of I-PRF

The potential of I-PRF in medicine and aesthetics is continuously being researched and developed. The healing potential of growth factors and cellular components suggests that I-PRF will become even more widespread in the future. Additionally, the use of I-PRF in combined treatments is being researched and shows promise.


Injectable I-PRF offers a natural and biocompatible treatment option derived from the patient's own blood. It has a wide range of applications, from dentistry to orthopedics, dermatology to aesthetic applications. I-PRF provides both rapid healing and long-lasting effects, making it an increasingly important treatment method in the future.

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